Journal Club 220427

Nifuji introduced a paper entitled “Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair” in Sci. Adv., 7 (23), eabd9371, which showed that Prdm16 localizes at the NL where it cooperates with the H3K9 methyltransferases G9a/GLP to mediate tethering and silencing of myogenic genes, repressing an alternative myogenic fate in fibro-adipogenic progenitors.