Journal Club 220127

Nifuji introduced a paper entitled “Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements (Stem Cell Reports  Vol. 14 ,60–74, January 14, 2020)”, which showed that L1 elements are expressed and mobilized during the initial stages of reprogramming and that their insertions into specific acceptor loci coincides with higher chromatin accessibility.