Publications

2022

H. Ideno, K. Komatsu,K. Nakashima,A. Nifuji. Tooth transplantation and replantation: Biological insights towards therapeutic improvements. Genesis. 2022 Aug 2;e23496. doi: 10.1002/dvg.23496.

S. Kajikawa, Y. Ezura, Y. Izu, K. Nakashima, M. Noda, A. Nifuji.Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structuresbased on branched actin filaments. J Bone Miner Metab. 2022 Apr15. doi: 10.1007/s00774-022-01320-y.

K. Komatsu, H. Ideno, T. Shibata, Nakashima, A. Nifuji. Platelet-derived growth factor-BB regenerates functional periodontal ligament in the tooth replantation. Sci Rep. 2022 Feb 25;12(1):3223. doi: 10.1038/s41598-022-06865-6.

2006-2020

[1]H. Ideno, K. Nakashima, K. Komatsu, R. Araki, M. Abe, Y. Arai, H. Kimura, Y. Shinkai, M. Tachibana, A. Nifuji, G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development, Bone. 137 (2020). doi:10.1016/j.bone.2020.115332.

[2]N. Hayashi, T. Sato, S. Kokabu, M. Usui, M. Yumoto, E. Ikami, Y. Sakamoto, A. Nifuji, T. Hayata, M. Noda, T. Yoda, Possible association of oestrogen and Cryba4 with masticatory muscle tendon-aponeurosis hyperplasia, Oral Dis. 25 (2019). doi:10.1111/odi.12876.

[3]A. Shimada, H. Ideno, Y. Arai, K. Komatsu, S. Wada, T. Yamashita, N. Amizuka, E. Pöschl, B. Brachvogel, Y. Nakamura, K. Nakashima, H. Mizukami, Y. Ezura, A. Nifuji, Annexin A5 Involvement in Bone Overgrowth at the Enthesis, J. Bone Miner. Res. 33 (2018) 1532–1543. doi:10.1002/jbmr.3453.

[4]Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nat Commun. 2018 Jul 19;9(1):2833. doi: 10.1038/s41467-018-05187-4.

[5]T. Kamiunten, H. Ideno, A. Shimada, Y. Arai, T. Terashima, Y. Tomooka, Y. Nakamura, K. Nakashima, H. Kimura, Y. Shinkai, M. Tachibana, A. Nifuji, Essential roles of G9a in cell proliferation and differentiation during tooth development, Exp. Cell Res. 357 (2017). doi:10.1016/j.yexcr.2017.05.016.

[6]N.C.-N. Huynh, V. Everts, A. Nifuji, P. Pavasant, R.S. Ampornaramveth, Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells, Bone. 95 (2017). doi:10.1016/j.bone.2016.11.017.

[7]M. Kawasaki, Y. Izu, T. Hayata, H. Ideno, A. Nifuji, V.C. Sheffield, Y. Ezura, M. Noda, Bardet-Biedl syndrome 3 regulates the development of cranial base midline structures, Bone. 101 (2017). doi:10.1016/j.bone.2016.02.017.

[8]C. Pawaputanon Na Mahasarakham, Y. Ezura, M. Kawasaki, A. Smriti, S. Moriya, T. Yamada, Y. Izu, A. Nifuji, K. Nishimori, Y. Izumi, M. Noda, BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells, J. Cell. Physiol. 231 (2016). doi:10.1002/jcp.25180.

[9]K. Komatsu, T. Shibata, A. Shimada, H. Ideno, K. Nakashima, Y. Tabata, A. Nifuji, Cationized gelatin hydrogels mixed with plasmid DNA induce stronger and more sustained gene expression than atelocollagen at calvarial bone defects in vivo, J. Biomater. Sci. Polym. Ed. 27 (2016). doi:10.1080/09205063.2016.1139486.

[10]M. Shirai, R. Yamamoto, T. Chiba, K. Komatsu, S. Shimoda, Y. Yamakoshi, S. Oida, C. Ohkubo, Bone augmentation around a dental implant using demineralized bone sheet containing biologically active substances, Dent. Mater. J. 35 (2016) 470–478. doi:10.4012/dmj.2016-026.

[11]S. Wada, H. Ideno, A. Shimada, T. Kamiunten, Y. Nakamura, K. Nakashima, H. Kimura, Y. Shinkai, M. Tachibana, A. Nifuji, H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro, Histochem. Cell Biol. 144 (2015). doi:10.1007/s00418-015-1318-2.

[12]H. Ideno, K. Nakashima, A. Nifuji, Roles of the histone methyltransferase G9a in the development and differentiation of mesenchymal tissues, J. Phys. Fit. Sport. Med. 4 (2015) 357–362. doi:10.7600/jpfsm.4.357.

[13]Y. Raita, K. Komatsu, T. Hayakawa, Pilot study of gingival connective tissue responses to 3-dimensional collagen nanofiber-coated dental implants, Dent. Mater. J. 34 (2015) 847–854. doi:10.4012/dmj.2015-095.

[14]T. Kamiunten, H. Ideno, A. Shimada, Y. Nakamura, H. Kimura, K. Nakashima, A. Nifuji, Coordinated expression of H3K9 histone methyltransferases during tooth development in mice, Histochem. Cell Biol. 143 (2014). doi:10.1007/s00418-014-1284-0.

[15]A. Shimada, S. Wada, K. Inoue, H. Ideno, T. Kamiunten, K. Komatsu, A. Kudo, Y. Nakamura, T. Sato, K. Nakashima, A. Nifuji, Efficient expansion of mouse primary tenocytes using a novel collagen gel culture method, Histochem. Cell Biol. 142 (2014) 205–215. doi:10.1007/s00418-014-1191-4.

[16]Y. Raita, K. Komatsu, A. Nifuji, M. Sato, M. Morito, T. Hayakawa, Promotion of bone formation around alendronate-immobilized screw-type titanium implants after implantation into rat molar tooth sockets, J. Hard Tissue Biol. 23 (2014). doi:10.2485/jhtb.23.177.

[17]H. Ideno, A. Shimada, T. Kamiunten, K. Imaizumi, Y. Nakamura, H. Kimura, R. Araki, M. Abe, K. Nakashima, A. Nifuji, Search for Conditions to Detect Epigenetic Marks and Nuclear Proteins in Immunostaining of the Testis and Cartilage, J. Histol. 2014 (2014) 658293. doi:10.1155/2014/658293.

[18]K. Komatsu, A. Shimada, T. Shibata, S. Wada, H. Ideno, K. Nakashima, N. Amizuka, M. Noda, A. Nifuji, Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model, J. Endocrinol. 219 (2013) 145–158. doi:10.1530/JOE-13-0040.

[19]R. Araki, M. Uda, Y. Hoki, M. Sunayama, M. Nakamura, S. Ando, M. Sugiura, H. Ideno, A. Shimada, A. Nifuji, M. Abe, Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells., Nature. 494 (2013) 100–4. http://www.ncbi.nlm.nih.gov/pubmed/23302801.

[20]H. Ideno, A. Shimada, K. Imaizumi, H. Kimura, M. Abe, K. Nakashima, A. Nifuji, Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development, Gene Expr. Patterns. 13 (2013). doi:10.1016/j.gep.2013.01.002.

[21]A. Shimada, K. Komatsu, K. Nakashima, E. Pöschl, A. Nifuji, Improved methods for detection of β-galactosidase (lacZ) activity in hard tissue, Histochem. Cell Biol. 137 (2012) 841–847.

[22]K. Yumoto, A. Nifuji, S.R. Rittling, Y. Tsuchiya, S. Kon, T. Uede, D.T. Denhardt, H. Hemmi, T. Notomi, T. Hayata, Y. Ezura, T. Nakamoto, M. Noda, Osteopontin Deficiency Suppresses Tumor Necrosis Factor-α-Induced Apoptosis in Chondrocytes, Cartilage. 3 (2012). doi:10.1177/1947603511421502.

[23]Y. Higashino-Matsui, K. Shirato, Y. Suzuki, Y. Kawashima, Y. Someya, S. Sato, A. Shiraishi, M. Jinde, A. Matsumoto, H. Ideno, K. Tachiyashiki, K. Imaizumi, Age-related effects of fasting on ketone body production during lipolysis in rats, Environ. Health Prev. Med. 17 (2012) 157–163. doi:10.1007/s12199-011-0231-0.

[24]A.N. Natali, P.G. Pavan, C. Venturato, K. Komatsu, Constitutive modeling of the non-linear visco-elasticity of the periodontal ligament, Comput. Methods Programs Biomed. 104 (2011) 193–198. doi:10.1016/j.cmpb.2011.03.014.

[25]Y. Kawashima, Y. Someya, K. Shirato, S. Sato, H. Ideno, K. Kobayashi, K. Tachiyashiki, K. Imaizumi, Single administration effects of ethanol on the distribution of white blood cells in rats, J. Toxicol. Sci. 36 (2011) 347–355. doi:10.2131/jts.36.347.

[26]Y. Sakakibara, S. Sato, K. Shirato, N. Arai, S. Aritoshi, N. Ogawa-Nakata, Y. Kawashima, Y. Someya, S. Akimoto, M. Jinde, A. Shiraishi, H. Ideno, K. Tachiyashiki, K. Imaizumi, Dietary zinc-deficiency and its recovery responses in the thermogenesis of rats, J. Toxicol. Sci. 36 (2011) 681–685. doi:10.2131/jts.36.681.

[27]A. Nifuji, H. Ideno, Y. Ohyama, R. Takanabe, R. Araki, M. Abe, M. Noda, H. Shibuya, Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation, Exp. Cell Res. 316 (2010) 1127–1136.

[28]A. Nifuji, H. Ideno, R. Takanabe, M. Noda, Extracellular modulators regulate bone morphogenic proteins in skeletal tissue, J. Oral Biosci. 52 (2010). doi:10.2330/joralbiosci.52.311.

[29]K. Komatsu, Mechanical strength and viscoelastic response of the periodontal ligament in relation to structure., J. Dent. Biomech. 2010 (2010) 1–18. doi:10.4061/2010/502318.

[30] Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, Nakamura T, Kato S, Miyasaka N, Ezura Y, Noda M. Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem. 2010 Apr 1;109(5):866-75.

[31]H. Ideno, R. Takanabe, A. Shimada, K. Imaizumi, R. Araki, M. Abe, A. Nifuji, Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro, Exp. Cell Res. 315 (2009) 474–484.

[32] Saita Y, Nakamura T, Mizoguchi F, Nakashima K, Hemmi H, Hayata T, Ezura Y, Kurosawa H, Kato S, Noda M. Combinatory effects of androgen receptor deficiency and hind limb unloading on bone. Horm Metab Res. 2009 Nov;41(11):822-8. Epub 2009 Jul 23.PMID: 19629928

[33] Hayashi C, Hasegawa U, Saita Y, Hemmi H, Hayata T, Nakashima K, Ezura Y, Amagasa T, Akiyoshi K, Noda M. Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor. J Cell Physiol. 2009 Jul;220(1):1-7.PMID: 19301257

[34] Izu Y, Mizoguchi F, Kawamata A, Hayata T, Nakamoto T, Nakashima K, Inagami T, Ezura Y, Noda M. Angiotensin II type 2 receptor blockade increases bone mass. J Biol Chem. 2009 Feb 20;284(8):4857-64. Epub 2008 Nov 11.PMID: 19004830

[35]        A. Shimada, T. Shibata, K. Komatsu, A. Nifuji, Improved methods for immunohistochemical detection of BrdU in hard tissue, J. Immunol. Methods. 339 (2008) 11–16.

[36]        K. Komatsu, A. Shimada, T. Shibata, S. Shimoda, S. Oida, K. Kawasaki, A. Nifuji, Long-term effects of local pretreatment with alendronate on healing of replanted rat teeth, J. Periodontal Res. 43 (2008). doi:10.1111/j.1600-0765.2007.01012.x.

[37]        A. Kawamata, Y. Izu, H. Yokoyama, T. Amagasa, E.F. Wagner, K. Nakashima, Y. Ezura, T. Hayata, M. Noda, JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion, J. Cell. Biochem. 103 (2008) 1037–1045. doi:10.1002/jcb.21660.

[38]        C.J. Chung, K. Soma, S.R. Rittling, D.T. Denhardt, T. Hayata, K. Nakashima, Y. Ezura, M. Noda, OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application, J. Cell. Physiol. 214 (2008) 614–620. doi:10.1002/jcp.21250.

[39] Nagashima G, Okamoto N, Okuda M, Nakashima K, Noda M, Itokawa H, Suzuki R, Fujimoto T, Marumo K. Effect of linezolid against postneurosurgical meningitis caused by methicillin-resistant Staphylococcus epidermidis: case report. J Infect Chemother. 2008 Apr;14(2):147-50. Epub 2008 Apr 30.PMID: 18622679

[40] Ono N, Nakashima K, Rittling SR, Schipani E, Hayata T, Soma K, Denhardt DT, Kronenberg HM, Ezura Y, Noda M. Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts. J Biol Chem. 2008 Jul 11;283(28):19400-9. Epub 2008 Apr 16.PMID: 18417476

[41] Mizoguchi F, Mizuno A, Hayata T, Nakashima K, Heller S, Ushida T, Sokabe M, Miyasaka N, Suzuki M, Ezura Y, Noda M. Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. J Cell Physiol. 2008 Jul;216(1):47-53.PMID: 18264976

[42] Kawamata A, Izu Y, Yokoyama H, Amagasa T, Wagner EF, Nakashima K, Ezura Y, Hayata T, Noda M. JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion. J Cell Biochem. 2008 Mar 1;103(4):1037-45.PMID: 18240141

[43] Chung CJ, Soma K, Rittling SR, Denhardt DT, Hayata T, Nakashima K, Ezura Y, Noda M. OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application. J Cell Physiol. 2008 Mar;214(3):614-20.PMID: 17894420

[44] Kato N, Hasegawa U, Morimoto N, Saita Y, Nakashima K, Ezura Y, Kurosawa H, Akiyoshi K, Noda M. Nanogel-based delivery system enhances PGE2 effects on bone formation. J Cell Biochem. 2007 Aug 1;101(5):1063-70.PMID: 17520665

[45]        K. Hino, T. Nakamoto, A. Nifuji, M. Morinobu, H. Yamamoto, Y. Ezura, M. Noda, Deficiency of CIZ, a nucleocytoplasmic shuttling protein, prevents unloading-induced bone loss through the enhancement of osteoblastic bone formation in vivo, Bone. 40 (2007). doi:10.1016/j.bone.2006.03.019.

[46]        T. Kanda, Y. Yoshida, Y. Izu, A. Nifuji, Y. Ezura, K. Nakashima, M. Noda, PlexinD1 deficiency induces defects in axial skeletal morphogenesis, J. Cell. Biochem. 101 (2007) 1329–1337.

[47]        A. Shimoyama, M. Wada, F. Ikeda, K. Hata, T. Matsubara, A. Nifuji, M. Noda, K. Amano, A. Yamaguchi, R. Nishimura, T. Yoneda, Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function, Mol. Biol. Cell. 18 (2007). doi:10.1091/mbc.E06-08-0743.

[48]        M. Ishijima, K. Tsuji, S.R. Rittling, T. Yamashita, H. Kurosawa, D.T. Denhardt, A. Nifuji, Y. Ezura, M. Noda, Osteopontin is required for mechanical stress-dependent signals to bone marrow cells, J. Endocrinol. 193 (2007). doi:10.1677/joe.1.06704.

[49]        K. Washio-Oikawa, T. Nakamura, M. Usui, M. Yoneda, Y. Ezura, I. Ishikawa, K. Nakashima, T. Noda, T. Yamamoto, M. Noda, Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions, J. Bone Miner. Res. 22 (2007) 1217–1223. doi:10.1359/jbmr.070411.

[50]        N. Ono, K. Nakashima, E. Schipani, T. Hayata, Y. Ezura, K. Soma, H.M. Kronenberg, M. Noda, Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption, J. Biol. Chem. 282 (2007) 25509–25516. doi:10.1074/jbc.M610782200.

[51]        N. Kato, U. Hasegawa, N. Morimoto, Y. Saita, K. Nakashima, Y. Ezura, H. Kurosawa, K. Akiyoshi, M. Noda, Nanogel-based delivery system enhances PGE2 effects on bone formation, J. Cell. Biochem. 101 (2007) 1063–1070. doi:10.1002/jcb.21160.

[52]        M.M. Ali, T. Yoshizawa, O. Ishibashi, A. Matsuda, M. Ikegame, J. Shimomura, H. Mera, K. Nakashima, H. Kawashima, PIASxβ is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts, J. Cell Sci. 120 (2007) 2565–2573. doi:10.1242/jcs.005090.

[53]        Y. Saita, T. Takagi, K. Kitahara, M. Usui, K. Miyazono, Y. Ezura, K. Nakashima, H. Kurosawa, S. Ishii, M. Noda, Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia, J. Biol. Chem. 282 (2007) 12907–12915. doi:10.1074/jbc.M611203200.

[54]        N. Kato, K. Kitahara, S.R. Rittling, K. Nakashima, D.T. Denhardt, H. Kurosawa, Y. Ezura, M. Noda, Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone, J. Endocrinol. 193 (2007) 171–182. doi:10.1677/joe.1.06917.

[55]        C. Hayashi, S. Rittling, T. Hayata, T. Amagasa, D. Denhardt, Y. Ezura, K. Nakashima, M. Noda, Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration, J. Cell. Biochem. 101 (2007) 979–986. doi:10.1002/jcb.21298.

[56]        K. Komatsu, T. Shibata, A. Shimada, Analysis of contribution of collagen fibre component in viscoelastic behaviour of periodontal ligament using enzyme probe, J. Biomech. 40 (2007) 2700–2706. doi:10.1016/j.jbiomech.2006.12.004.

[57]        Y. Koyama, S.R. Rittling, K. Tsuji, K. Hino, R. Salincarnboriboon, T. Yano, Y. Taketani, A. Nifuji, D.T. Denhardt, M. Noda, Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts, Endocrinology. 147 (2006). doi:10.1210/en.2005-0671.

[58]        M. Ishijima, Y. Ezura, K. Tsuji, S.R. Rittling, H. Kurosawa, D.T. Denhardt, M. Emi, A. Nifuji, M. Noda, Osteopontin is associated with nuclear factor κB gene expression during tail-suspension-induced bone loss, Exp. Cell Res. 312 (2006). doi:10.1016/j.yexcr.2006.06.003.

[59]        K. Hino, A. Nifuji, M. Morinobu, K. Tsuji, Y. Ezura, K. Nakashima, H. Yamamoto, M. Noda, Unloading-induced bone loss was suppressed in gold-thioglucose treated mice, J. Cell. Biochem. 99 (2006). doi:10.1002/jcb.20935.

[60]        K. Washio-Oikawa, T. Nakamura, M. Usui, M. Yoneda, Y. Ezura, I. Ishikawa, K. Nakashima, T. Yamamoto, M. Noda, Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro, J. Cell. Biochem. 99 (2006) 538–544. doi:10.1002/jcb.20854.

[61]        A. Shimada, K. Komatsu, T. Shibata, M. Chiba, Effects of an intravenous infusion of Ringer’s solution on eruption rates of incisor teeth in anesthetized rats, Acta Odontol. Scand. 64 (2006) 16–20. doi:10.1080/00016350500331104.

[62]        T. Shibata, A. Yamane, A. Shimada, J. Nagata, K. Komatsu, Practical method using software to simulate pharmacokinetics: Its application to practical training of pharmacology for undergraduate dental students, Folia Pharmacol. Jpn. 127 (2006) 467–471. doi:10.1254/fpj.127.467.

[63]        T. Shibata, J. Botsis, M. Bergomi, A. Mellal, K. Komatsu, Mechanical behavior of bovine periodontal ligament under tension-compression cyclic displacements, Eur. J. Oral Sci. 114 (2006) 74–82. doi:10.1111/j.1600-0722.2006.00269.x.

[63]        A. Shimada, K. Komatsu, M. Chiba, Effects of local injections of vasoactive drugs on eruption rate of incisor teeth in anaesthetized rats, Arch. Oral Biol. 51 (2006) 449–456. doi:10.1016/j.archoralbio.2005.11.001.